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0-5 years of experience
Designed statistically optimized experimental plans to investigate new processes and guide company strategic direction.
- Improved product characteristics through collaboration with operations, engineering and science teams.
- Achieved threefold increase in production at the pilot scale through modification of core process.
- Analyzed and communicated data sets and project progress updates to science group and senior management.
- Managed production schedule of materials at pilot facility to meet internal deadlines.
- Developed procedures and trained operators for daily pilot plant production, reducing required scientific staff by half.
0-5 years of experience
Conduct research and development programs in fuel cell and battery technologies. Perform daily experiments, measurements, production, and reporting. Develop and test new plasma etching procedures, new alloys, and new metals. Design experiments, collect and analyze data, and prepare reports for corrosion resistant metal plates for flow batteries project.
- Part of team that completed $1 million Department of Energy research project that led to being awarded $2 million phase 2 project.
- Known to consistently deliver products and research on time and within budget and specifications.
- Developed new methods that enabled company to win new research funding.
- Redesigned sample carrier to increase capacity that drove productivity by about 20%.
0-5 years of experience
Developed cleaning solutions for use in the semiconductor industry. Prepare and present customer as well as internal reports and presentations.
- Project leader: developed a greener wafer reclaim formulation designed to remove metal, barrier metal and dielectric layers without damaging silicon substrate; directed a multi-site R&D team including 3 people (1 scientist, 2 junior chemists) on site, this project was the number one initiative of [company name] for 2008, prepared scale up / product demo at partner site
- Member of emergency response team trained to respond to gas / chemical releases and medical emergencies
- New hire mentor and interview panelist
- Member of the committee that instituted a new rewards and recognition program for R&D and manufacturing employees located in Danbury
- Efforts resulted in the submission of two patent applications
6-10 years of experience
Designed assays to evaluate novel drugs, with an emphasis on cellular pathways involving the enzymes poly-ADP-ribose polymerase, poly-ADP ribose glycohydrolase, cyclophilins and sirtuins.
- Determined the mechanism of action and kinetics of PARP inhibitors.
- Analyzed the effect of PARP inhibitors on gene expression by microarray analysis.
- Created a clinical biomarker ELISA assay for PARP inhibitors using B16 melanoma models.
- Identified and validated new drug targets and developed cellular models.
- Gained extensive experience in cDNA cloning, PCR, protein purification, siRNA design and gene silencing, microarray analysis, bioassay development, northern and western blotting, ELISA, enzyme inhibitor dissociation analysis, matrigel invasion assays, and use of automation in HTS.
6-10 years of experience
Independently designed, executed, analyzed, and reported results on relatively complex in vitro experiments.
- Assessed, validated, and implemented drug transporter assays (OATP, BCRP, Pgp, hepatocyte uptake) to evaluate compounds in pre-clinical development to predict possible drug-drug interactions.
- Led a worldwide taskforce to harmonize OATP inhibtion assays, data analysis, and protocol/report documents.
- Ordered, installed and validated Tecan liquid handling robot.
- Provided CYP450 induction support using TaqMan for toxicology studies.
- Assisted in establishing and validating TaqMan technology.
- Supervised student co-op.
0-5 years of experience
Established business need for on-press developable UV-sensitive printing plate R&D program.
- Gained full management support to deliver a short and long run lithographic printing plate
- Hired, trained and led the formulation team for the photoactive layer to deliver final product
- Identified coating conditions to improve on-press performance to 25,000 impressions, the minimum for commercial viability
- Developed bench top screening technique that predicted on-press performance
0-5 years of experience
Conducted product feasibility design to pilot and large-scale manufacturing of following products for in vitro diagnostic quantitative determination resulting in final delivery of products as scheduled:
- Tri-Level Control Plasma - Antibody purification, affinity chromatography, formulation, lyophilization.
- Chromomeric Screening Assay for Protein C Pathway - consolidated 3 expensive assays to 1 assay.
- Factor XII Deficient Plasma - Immunodepletion of Factor XII in human plasma replaced OEM product.
- Designed and developed biochemical assays and applied on high throughput automated analyzers.
- Managed technical transfer from R&D to manufacturing and product support operations by creating SOPs, Raw Material Monograms, Bill of Materials, Standard Production Methods, Quality Control Monograms and conducted training for process execution. Maintained Design History File.
- Drafted protocols, performed verification, validation and scale-up studies including POP, clinical studies, stability, interference and risk analysis studies, clinical trials, statistical data analysis and reports for FDA 510K submission.
6-10 years of experience
Research Scientist - Department of Cell & Molecular Biology
February 2010-Present
- Developed cell biology and Immunotoxicology based assays in a GLP compliant environment.
- Supervised and reviewed data of staff performing cell culture, molecular, and ELISA analysis.
- Trained staff and wrote SOPs focusing on novel immunology, cell biology and protein identification methodologies.
- Consulted clients on proper use of biomarkers for assessment of their test article
- Presented scientific lectures to the company for marketing/sales force education.
- Wrote technical reports regarding scientific implications of data generated and presented to clients.
0-5 years of experience
Worked alongside senior R&D scientists to develop products from concept to production scale
- Innovated, developed and scaled oil and cream based sauces in addition to the margarine products produced in our Arkansas facility, representing one-third of the total products produced
- Reverse engineered products to create an identical match or for use as a sensory match with varied functionality
- Designed and helped implement a protocol to measure and improve the quality of oil throughout the entire processing facility, with focus on oxidative and hydrolytic rancidity.
- Acted as a liaison between the oil processing facility and upper level R&D, as well as top management
- Communicated complex methodologies used during the development and production of all products to top management
- Designed sensory tests to determine organoleptic variations between oil based products
- Utilized refractometry, pH, water activity, colormetric, percent moisture, percent salt, and titratable acidity as quantifiable metrics to analyze products.
0-5 years of experience
Target Identification and validation using intestinal organoid models and stable cancer cell lines.
- Developed transgenic mouse models (CDX2 and b-catenin) to assess role of Wnt signaling in colon cancer progression.
- Extracted RNA from mammalian cells and tissue samples and performed real time PCR.
- Extracted DNA from the tails and toes of mice.
- Modified and documented in the protocol book daily.
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